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Articles by Charlotte Maden
Worlds-first successful pig-to-human heart transplant
Worlds-first successful pig-to-human heart transplant 17 January 2022 Appeared in BioNews 1128 Surgeons have successfully transplanted a pig heart into a human recipient for the first time, enabled by genome editing. In a world first, researchers have genetically engineered a pig heart to resist transplant immune rejection in a human patient.
Infertility risk linked to air pollution
Infertility risk linked to air pollution 22 February 2021 Appeared in BioNews 1084 High pollution levels can increase the risk of infertility by up to 20 percent, a study in China has found. The researchers wrote that their findings point to pollution as 'an unignorable risk factor for infertility'. It is believed to be the first study that examines the link between air pollution and infertility in the general population, rather than solely in fertility patients.
'Molecular signature' of childhood trauma discovered in men's sperm
Scientists have discovered alterations in the sperm cell DNA of adult men who had been abused as children. Men who had experienced childhood abuse carried epigenetic markers – which alter gene expression – that appeared to be linked to their early-life trauma. 'We can look at our study as one small piece in the huge overall puzzle of how intergeneration trauma works,' said study author Nicole Gladish, a PhD candidate at the University of British Columbia in Canada.
Epigenetics of addiction relapse probed using rats
Researchers have identified how the likelihood of cocaine addiction relapse is influenced by epigenetic changes in rats. The findings could be used to understand why drug users relapse and potentially devise new therapies. 'Our goal was to discover the brain mechanisms responsible for the rewarding effects of the drug and the motivation to seek it even after long periods of abstinence,' said lead researcher Professor Christopher Cowan of the Medical University of South Carolina (MUSC).
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