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Abstract Background: Systemic inflammation is increasingly recognized as a key determinant of long-term health outcomes. The Inflammatory Burden Index (IBI), derived from C-reactive protein, neutrophil count, and lymphocyte count, integrates multiple components of systemic inflammatory and immune status. However, evidence regarding its association with long-term mortality among individuals with and without a history of cancer remains limited.
1. Introduction Click to copy section linkSection link copied! Gastric cancer (GC) remains a leading cause of global cancer-related morbidity and mortality, particularly in China, (1) where most patients are diagnosed at advanced stages with limited curative options. (2) Elucidating the molecular mechanisms driving GC progression is critical for developing effective prevention and treatment strategies.
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