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Abstract Glucocorticoids (GCs) serve as first-line immunosuppressive therapy for alopecia areata (AA), yet physiologically suppress hair growth and cycling. The molecular basis of this paradoxical effect remains incompletely understood, hindering optimization of GCs as.effective depilatory agents. Using transcriptomic data and immunofluorescence staining, we detected robust expression of the glucocorticoid receptor (GR, encoded by NR3C1) in caprine dermal papilla cells (DPCs) in vitro.
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