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Chhavi Sood

As seen in: BioRxiv, eLife
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Articles by Chhavi Sood

Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

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By Chhavi Sood, Ausrafuggaman Nahid, Kendall R. Branham, Matt Pahl
| eLife
eLife assessment This useful study reports on how Notch activity regulates the termination of neurogenesis in central brain during larval-pupal stages in Drosophila. The evidence supporting the claims is solid. The work will be of interest to developmental neurobiologists.
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Notch controls early temporal factor expression to control timing of Mushroom body neuroblast apoptosis

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By Kendall R. Branham, Chhavi Sood, Susan Doyle, Matt Pahl
| BioRxiv
Abstract The neurogenic period, where neural stem cells (NSCs) proliferate to produce molecularly distinct progeny in the developing brain, is a critical time of growth in many organisms. Proper brain development is crucial for survival and requires strict regulation of NSC divisions along a set developmental timeline. In Drosophila NSCs known as neuroblasts (NBs), cell intrinsic programs integrate with extrinsic cues to control periods of rapid growth through temporal patterning genes.
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Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

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By Matthew C. Pahl, Chhavi Sood, Ausrafuggaman Nahid, Kendall R. Branham
| BioRxiv
Summary Neuroblasts in Drosophila divide asymmetrically, sequentially expressing a series of intrinsic factors to generate a diversity of neuron types. These intrinsic factors known as temporal factors dictate timing of neuroblast transitions in response to steroid hormone signaling and specify early versus late temporal fates in neuroblast neuron progeny.
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