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Articles by Chi Sun
Phenotypic variability of a dominant CRX mutation and molecular insights into pathogenesis
ABSTRACT Background Mutations in the cone-rod homeobox (CRX) gene cause dominantly inherited retinopathies with striking phenotypic variability. We define the clinical spectrum and molecular mechanism of a Class III CRX frameshift variant (c.590del, p.(Pro197Argfs*22); CRXP197Rfs) segregating in a four-generation family. Materials and methods Six family members underwent genetic testing by a retinal dystrophy panel with Sanger confirmation.
A virtual reality system for court interpreting education and its effects on motivation and fluency based on self determination theory
Abstract Court interpreting is critical for ensuring fairness in the justice system. However, traditional training methods often lack engagement and fail to provide interpreters with sufficient hands-on experience, relying heavily on passive learning approaches. To address these limitations, we designed and implemented MetaCourt, a virtual reality (VR) environment for court interpreting training.
Inhibition of angiogenesis by propranolol in infantile hemangiomas via lncRNA NEAT1-mediated miR-194-5p/TRAF6/NF-κB pathway
Abstract Existing studies suggest that nuclear paraspeckle assembly transcript 1 (NEAT1) is involved in the biological behavior of endothelial cells by regulating angiogenesis. Treatment of infantile hemangioma (IH) with propranolol (Pro) has been shown to block nuclear factor-κB (NF-κB)-mediated angiogenesis. However, the underlying mechanisms remain unclear.
Ecological Health Evaluation of Yellow River Irrigation Districts in Henan Province: A Case Study of the Zhaokou Irrigation District
3.2. Fuzzy Comprehensive Evaluation and Functional Zoning of the Zhaokou Irrigation District 3.2.1. Zonal Health Evaluation According to the administrative division of the region where it is located, the Zhaokou irrigation district is divided into five areas, namely, Zhengzhou, Kaifeng, Zhoukou, Shangqiu, and Xuchang areas.
Characterization and antimicrobial resistance of Staphylococcus hyicus from swine exudative epidermitis in South Korea - BMC Veterinary Research
References Foster AP. Staphylococcal skin disease in livestock. Vet Dermatol. 2012;23. https://doi.org/10.1111/j.1365-3164.2012.01093.x. 342 – 51, e63. Andresen LO, Wegener HC, Bille-Hansen V. Staphylococcus hyicus-skin reactions in piglets caused by crude extracellular products and by partially purified exfoliative toxins. Microb Pathog. 1993;15:217–25. https://doi.org/10.1006/mpat.1993.1072.
Supercurrent-induced spin switching via indirect exchange interaction
Localized spins of single atoms adsorbed on surfaces have been proposed as building blocks for spintronics and quantum computation devices. However, identifying a way to achieve current-induced switching of spins with very low dissipation is an outstanding challenge with regard to practical applications. Here, we show that the indirect exchange interaction between spin impurities can be controlled by a dissipationless supercurrent.
Phys. Rev. B 109, 174520 (2024) - Strong-coupling approach to temperature dependence of competing orders of superconductivity: Possible time-reversal symmetry breaking and nontrivial topology
We use strong-coupling Eliashberg theory to study the competition of separate superconducting orders at low temperatures. Specifically, we study magnon-mediated superconductivity in a trilayer heterostructure with a thin normal metal between two antiferromagnetic insulators. Spin-triplet p-wave, spin-triplet f-wave, and spin-singlet d-wave superconducting gaps have been predicted to occur close to the critical temperature for the superconducting instability.
Numerical Simulation of Lost-Foam Casting for Key Components of A356 Aluminum Alloy in New Energy Vehicles
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors
1 Washington University School of Medicine in St. Louis ↵* Corresponding author; email: mwhite{at}genetics.wustl.edu Received May 27, 2023. Accepted February 1, 2024. This manuscript is Open Access. This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International license), as described at http://creativecommons.org/licenses/by/4.0/.
Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors
Abstract Dozens of variants in the photoreceptor-specific transcription factor (TF) CRX are linked with human blinding diseases that vary in their severity and age of onset. It is unclear how different variants in this single TF alter its function in ways that lead to a range of phenotypes.
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms
eLife assessment This manuscript will be of interest to readers in the field of neural development and neurodegeneration. The study is important as it examines two disease-causing mutations within the homeodomain transcription factor Cone-Rod Homeobox (CRX) that causes retinopathy in humans. The data are solid, and the work contributes to our understanding of the underlying pathogenetic mechanisms.
Spin pumping from a ferromagnetic insulator into an altermagnet
A class of antiferromagnets with spin-polarized electron bands, yet zero net magnetization, called altermagnets, is attracting increasing attention due to their potential use in spintronics. Here, we study spin injection into an altermagnet via spin pumping from a ferromagnetic insulator. We find that the spin pumping behaves qualitatively differently depending on how the altermagnet is crystallographically oriented relative to the interface of the ferromagnetic insulator.
Optimizing CO2 Hydrogenation to DME through Tailored Interfacial Interactions: Weakening Synergy in CuZnZr and Al-Modified SBA-15 Catalysts
Download Hi-Res ImageDownload to MS-PowerPointCite This:Ind. Eng. Chem. Res. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
The detection and phylogenetic characterization of Cryptosporidium, Cystoisospora, and Giardia duodenalis of cats in South Korea
Background With the growth of the pet industry in South Korea, interest in animal health, including cats, has increased, and gastrointestinal parasitic infections have received significant attention for the general health of cats (Kwak and Seo, 2020; Moon et al, 2022). The three most prevalent gastrointestinal protozoa parasites in cats are Cryptosporidium, Cystoisospora, and Giardia duodenalis.
Stability of superconducting gap symmetries arising from antiferromagnetic magnons
We consider a planar heterostructure consisting of a normal metal in proximity to an antiferromagnetic insulator, with an interlayer exchange coupling between the metal and the insulator. The coupling to the two sublattices of the antiferromagnetic insulator is allowed to be asymmetric. An effective electron-electron interaction in the normal metal, mediated by antiferromagnetic magnons in the insulator, is derived to second order in the interlayer exchange coupling.
Andreev reflection in altermagnets
Recent works have predicted materials featuring bands with a large spin-splitting distinct from ferromagnetic and relativistically spin-orbit-coupled systems. Materials displaying this property are known as altermagnets and feature a spin-polarized band structure reminiscent of a d-wave superconducting order parameter. We here consider the contact between an altermagnet and a superconductor and determine how the altermagnetism affects the fundamental process of Andreev reflection.
Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors
New Results doi: https://doi.org/10.1101/2023.05.27.542576 Abstract Dozens of variants in the photoreceptor-specific transcription factor (TF) CRX are linked with different human blinding diseases that vary in their severity and age of onset. How different variants in a single TF cause a range of pathological phenotypes is not understood.
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms
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Puerarin extends lifespan of Drosophila melanogaster by activating autophagy
Puerarin extends lifespan of Drosophila melanogaster by activating autophagy Ai-wen Kang, Chi Sun, Haitao Li , Kun Zhong, Xu-Hui Zeng, Zhifeng Gu, Bing-qian Li, Xiao-Ning Zhang, Jian-lin Gao and Tian-xing Chen Abstract Lifespan longevity has attracted increasing attention with societal development. To counter the effects of aging on longevity, we focused on the natural chemicals of plants.
Validation of a supplementary condition of eighth AJCC staging system for stage II hepatocellular carcinoma
The eighth American Joint Committee on Cancer (AJCC) staging system was flawed regarding the prognosis of stage II hepatocellular carcinoma (HCC). The aims of this study were to reveal the defect and make updates. Clinical and survival data of HCC patients from the Surveillance, Epidemiology, and End Results database were used. We re-classified stage II into T2aN0M0 (tumors >2 cm with vascular invasion) and T2bN0M0 (multiple tumors ≤5 cm).
Sustainable Remediation in China: Elimination, Immobilization, or Dilution
Remediation of land contaminated by pollutants is one of the biggest challenges of the Anthropocene era. In July 2021, The United Nations (UN) Food and Agriculture Organization (FAO) and Environment Program (UNEP) jointly published the “Global Assessment of Soil Pollution” report, (1) which was mandated by the third Session of the UN Environment Assembly, the world’s highest-level environmental decision-making body.
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