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Abstract Retinal ganglion cell (RGC) degeneration and the limited regenerative capacity of mammalian central nervous system axons result in irreversible vision loss in optic neuropathies. Identifying intrinsic regulators that promote both neuroprotection and axon regeneration is critical for developing effective therapies. This study identified POU domain class 2 transcription factor 2 (Pou2f2) as a previously unrecognized regulator involved in RGC biology.
Copper Cluster Complex Catalyzed C-S bond Formation A three distinct copper cluster complexes (A-C) containing Cu-O ligated Schiff-base ligands were synthesized and bonding was investigated by single crystal X-ray crystallographic studies. These complexes effectively catalyze the C-S cross coupling reaction of less reactive aliphatic thiols to synthesize thioether derivatives. This coupling reaction also tolerates well and compatible with aryl thiols.
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