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Chie Aoki-Utsubo on Muck Rack

Chie Aoki-Utsubo

As seen in: Nature, Wiley Online Library
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Articles by Chie Aoki-Utsubo

Statins enhance extracellular release of hepatitis C virus particles through ERK5 activation

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By Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Muhammad Bagas Hanafi
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , . Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013; 57: 1333–1342. 2, , . Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer. 2013; 13: 123–135. 3, . Hepatitis C virus infection. N Engl J Med. 2001; 345: 41–52. 4, , , , , , et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.
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Broad-spectrum antiviral agents: secreted phospholipase A 2 targets vi

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By Ming Chen, Lin Deng, Chie Aoki-Utsubo, Masanori Kameoka
| Nature Verified
First, we tested the possible direct virucidal activity of CM-II-sPLA (UniProtKB-P00603 [PA2B2_NAJMO]) against infectious particles of a panel of viruses. Each virus was incubated with various concentrations of CM-II-sPLA or medium as a control at 37?°C for 1?h and then inoculated onto Huh7it-1 cells. After 1?h of virus adsorption, the residual virus was removed by washing the cells with medium and the cells were cultured for 24?h.
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