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Articles by Chintan Soni
Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases
Cite Jump to ExpandCollapse ArticleFebruary 27, 2026 Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases Click to copy article linkArticle link copied! Chintan Soni Chintan Soni Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States Meghan Pressimone Meghan Pressimone Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, United States...
Dense vs Sparse Vectors in AI - Explained for Developers
Dense vs Sparse Vectors in AI — Explained for Developers When people talk about AI, embeddings, or semantic search, one concept quietly sits underneath almost everything: Vectors. And more specifically — dense vectors and sparse vectors. I recently published Video #2 in my AI Foundations for Developers series, where I break this down with simple mental models and real-world examples, without diving into heavy math or ML theory.
AI Foundations for Developers #1: What Are Vectors?
I’ve started a new video series called AI Foundations for Developers. This series is aimed at software engineers who want to understand how modern AI systems work from first principles — not just by using frameworks or copying code. Most AI content today jumps straight into tools like LangChain, RAG pipelines, or AI agents. But without understanding the basics, it’s hard to reason about design choices or debug issues in production.
Node.js Just Got Cooler: Imports and Package JSON Are Here to Save Your Day
If you’ve ever worked on a Node.js project, you’ve probably had this experience: You’re writing an import, your brain says “easy-peasy”, but your editor whispers: import service from "./../../../path/to/some/service.ts"; Suddenly, you’re not coding anymore. You’re Indiana Jones, lost in a temple of ../ and praying you don’t accidentally end up in the wrong directory. Well, guess what? Node.js just threw us a lifeline.
Node.js Just Got Cooler: Native TypeScript and Watch Mode Are Here to Party
Node.js just rolled up in sunglasses, holding a smoothie, and said, “Guess who supports TypeScript natively now?” That’s right—it’s leveling up in a big way. With built-in TypeScript support and a brand new watch mode, you can finally spend less time wrangling build tools and more time pretending to debug while secretly scrolling memes. 1. Native TypeScript Support: No Compiler? No Problem. Remember the old days when you had to run tsc just to breathe near a TypeScript file? That’s history.
Understanding JavaScript's Event Loop: A Simple Cookie-Making Analogy 🍪
When learning JavaScript, the event loop is one of those tricky topics that can leave you scratching your head. But don’t worry! We’re going to explain it in a fun and simple way using a real-world example that even a 5-year-old would understand: making cookies! 🎉 Let’s imagine you’re in the kitchen and want to bake a batch of cookies. But here’s the catch—you can only do one thing at a time.
GitLab CI/CD Pipelines: Best Practices for Monorepos
Hello everyone! This article is for those who want to optimize their CI/CD pipelines using best practices in a monorepo setup. To provide a clear walkthrough, let’s consider the following example: Project structure: Initial .gitlab-ci.yml: stages: - build - test - deploy build-a: stage: build script: - ... test-a: stage: test script: - ... deploy-a: stage: deploy script: - ... build-b: stage: build script: - ... test-b: stage: test script: - ... deploy-b: stage: deploy script: - ...
A translation-independent directed evolution strategy to engineer aminoacyl-tRNA synthetases
Abstract Using directed evolution, engineered aminoacyl-tRNA synthetases (aaRS) have been developed that enable co-translational incorporation of numerous noncanonical amino acids (ncAAs) into proteins in living cells. Until now, the selection of such novel aaRS mutants has relied on coupling their activity to the expression of a reporter protein with a selectable phenotype.
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Ecolibrium Launches SmartSense Discovery to Help UK Businesses Visualise Carbon Emissions and Accelerate Net Zero Journeys
Ecolibrium, the machine learning decarbonisation platform for industrial and commercial buildings, has announced the launch of SmartSense Discovery, a new tool that enables companies to identify, benchmark and manage the carbon footprint of their entire portfolio within 48 hours of onboarding. SmartSense Discovery has been developed to give companies an instant snapshot of the energy cost, use and carbon intensity of their buildings and portfolios.
Balancing people, planet and profits
By Chintan Soni, CEO and Co-Founder of Ecolibrium Research from the World Economic Forum has found that the built environment is responsible for 40 per cent of global energy consumption and 33 per cent of greenhouse gas emissions, with one-fifth of the world’s largest 2,000 companies adopting net zero strategies by 2050 or earlier. As one of the world’s largest emitters of greenhouse gases, the real estate industry must unite to decarbonise our planet.
Technology critical to drive efficiency
Smart and sustainable solutions, drawing on cutting-edge tech such as machine learning and artificial intelligence (AI), are here now – and can make a material contribution to reducing energy consumption while slashing the carbon footprint of buildings. Real estate’s recent energy efficiency push was initially driven by net zero ambitions – but the spiralling price of energy is now another key issue facing landlords.
Abbott Corporate: Enhancing marketing efforts using DMP
Abbott Laboratories, a pharmaceutical company, launched a campaign in India to boost overall reach by five million, reduce cost per view (CPV) by 50% and cost per thousand impressions (CPM) by 22%.
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