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Abstract Background: Metabolic syndrome (MetS) is a cluster of risk factors that increases cardiometabolic disease and mortality. A continuous MetS Score has been developed to quantify MetS severity, but its association with all-cause mortality in older Chinese adults remains unclear. Methods: We analyzed 2,443 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS, 2008–2018 and 2011–2018).
Abstract As global aging intensifies, elucidating reproductive health’s epigenetic aging associations is crucial. However, the impact of reproductive history on multi-generational DNA methylation (DNAm) clocks remains insufficiently characterized, representing a significant gap in understanding biological vs. chronological aging divergence.
ABSTRACT Persistent organic pollutants (POPs) are environmental contaminants linked to adverse health outcomes, but their impact on epigenetic aging remains incompletely characterized. This study investigated associations between serum concentrations of POPs and DNA methylation (DNAm)-based age acceleration using twelve established epigenetic clocks in 815 U.S. adults aged ≥50 years from NHANES 1999–2002.
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