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By Elise Devaux & Dr. Christoph Wehmeyer, Statice Synthetic data became a mainstream resource for various applications. It refers to data algorithmically generated approximating original data. The need for it can be a matter of data availability, cost reduction, security, or privacy concerns. Virtually all industries relying on personal or sensitive data to function can benefit from synthetic data.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Mdm2 is a major therapeutic target that antagonizes the tumor suppressor p53 by ubiquitinating it or by binding the N-terminal trans-activation domain (TAD) of p53. In certain cancers, Mdm2 is over-expressed leading to excessive inactivation of p5354. Therefore the Mdm2–p53 interaction is a primary target for inhibitor design55,56,57. The 12-amino-acid peptide PMI (p53–Mdm2/MdmX inhibitor) is one of the strongest known Mdm2 binders, with a dissociation constant of K ?=?3.3?nM57.
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