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Articles by Christopher A. McDevitt
Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment
Abstract Clinical failure of antibiotic therapy can occur in the absence of measurable resistance, yet the biological basis of this discordance remains poorly understood. Here, we identify a transient survival phenotype that limits dalbavancin efficacy and may contribute to treatment failure in the absence of stable resistance in Staphylococcus aureus.
L-type pyocins inhibit the BAM complex to kill without cell entry
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Abstract Many antibiotics are ineffective against the Gram-negative pathogen Pseudomonas aeruginosa because of intrinsic defence mechanisms, such as the impermeable bacterial outer membrane. Here, we show that protein antibiotics called L-type pyocins kill P. aeruginosa by inhibiting the β-barrel assembly machinery (BAM) complex at the cell surface, halting outer-membrane protein assembly.
By Fabian Munder, Matthew Johnson, Imogen Samuels, Laura Christine McCaughey, Oleksii Zdorevskyi, Chunxiao Wang, Ashleigh Kropp, Lauren Zavan, Erin Price, Derek S Sarovich, Swati Varshney, Christopher A. McDevitt, Hari Venugopal, Vivek Sharma, Matthew Doyle, Francesca L. Short, Debnath Ghosal, James Connolly, Gavin J. Knott, Rhys Grinter
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Nature
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Intracellular zinc protects tumours from T cell-mediated cytotoxicity - Cell Death & Differentiation
Abstract Tumour immune evasion presents a significant challenge to the effectiveness of cancer immunotherapies. Recent advances in high-throughput screening techniques have uncovered that loss of antigen presentation and cytokine signalling pathways are central mechanisms by which tumours evade T cell immunity.
COO Chris McDevitt Discusses Using Emotional Intelligence to Build Productive Teams | JD Supra
Chris McDevitt, COO of MG+M The Law Firm, discusses the importance emotional intelligence to ensure continued success and longevity at law firms. "Using EI to understand the composition of your team and what motivates them builds confidence and productivity," he writes.
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