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Articles by Christopher Johns
Public debt and monetary policy transmission: evidence from advanced and emerging Europe
Focus In standard models of monetary policy, public debt is assumed to have no role. Policy rate changes affect output and inflation through conventional channels, and any fiscal consequences of interest rate changes are assumed to be offset by corresponding adjustments in fiscal policy. However, with public debt high in many economies, this assumption may no longer be innocuous.
Hepatic metastasis surveillance in uveal melanoma: a retrospective cohort study from a UK tertiary centre (2006–2022)
Abstract Liver surveillance imaging is essential for detecting early asymptomatic metastases in uveal melanoma, which predominantly involves the liver. Early detection may improve treatment opportunities, but variability in imaging protocols and a lack of consensus on surveillance duration present challenges. This study aimed to evaluate our systemic surveillance protocol, optimise pathways, and assess risk factors for metastasis.
16319 Little Pine Creek Dr, Humble, TX 77346, US
Operating Expenses Recurring costs required to maintain and manage a rental property, including property taxes, insurance, maintenance, repairs, utilities (if paid by the owner), property management fees, and other day-to-day expenses. Calculation: Insurance + Property Taxes + Property Management + Repairs & Maintenance + Capital Expenditures + HOA Fees
Leibniz and the Religion of the Mohammadans
1. Introduction In the extant literature, several key papers have focused on Leibniz’s interests in Islam, or what Leibniz variously called Mahometism, the religion of the Turks, or the religion of the Mohammadans.
The Invention Stack: Harvesting And Protecting Intellectual Property
In his book The Innovation Stack, Jim McKelvey describes going "'nose-to-toe' against the world's most dangerous company" and surviving. McKelvey, who co-founded Square with Jack Dorsey in 2009, recalls Amazon copying Square's product and undercutting its pricing. But after about six years, Amazon discontinued its competing product – and even mailed a Square card reader to its former customers. Naturally, this raised questions. Why did Amazon discontinue its competing product?
Parameterizing Debt Maturity
Supporting Information Filename Description jmcb13116-sup-0001-Appendix.pdf1.9 MB Figure A1: Face value of total and marketable debt outstanding, 1869-2020. Figure A2: Imputed inflation forecast parameter estimates. Figure A3: United Kingdom RPI inflation expectations, 1981-2020. Figure A4: US Treasury Statement of the Public Debt, January 31, 1930. Figure A5: Marketable debt; comparison to CRSP, Hall et al. [2021], and headline data.
Voxel-Wise Comparison of Co-Registered Quantitative CT and Hyperpolarised Gas Diffusion-Weighted MRI Measurements in IPF
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Supreme Court Declines To Clarify The Abstract-Idea Exception To Patentability In Interactive Wearables And Tropp
The Supreme Court in Interactive Wearables LLC v. Polar Electro Oy and Tropp, David A. v. Travel Sentry, Inc., et al. declined to hear a pair of cases that could have clarified the abstract-idea exception to patent eligibility. No. 21-1281, 2023 WL 3440746, at *1 (U.S. May 15, 2023); No. 22-22, 2023 WL 3440747 (U.S. May 15, 2023). No opinion was issued, but the Court noted that Justice Kavanaugh would have heard the cases.
People.ai: Reaffirmation That Automation Alone Is Insufficient
On April 7, the Federal Circuit handed down a non-precedential opinion on People.ai, Inc., v. Clari Inc., reaffirming the holding that automation or digitalization of a conventional method of organizing human activity does not bring the claims out of the realm of abstractness.
People.ai: Reaffirmation That Automation Alone Is Insufficient
On April 7, the Federal Circuit handed down a non-precedential opinion on People.ai, Inc., v. Clari Inc., reaffirming the holding that automation or digitalization of a conventional method of organizing human activity does not bring the claims out of the realm of abstractness.
Supreme Court Declines to Clarify the Abstract-Idea Exception to Patentability in Interactive Wearables and Tropp
The Supreme Court in Interactive Wearables LLC v. Polar Electro Oy and Tropp, David A. v. Travel Sentry, Inc., et al. declined to hear a pair of cases that could have clarified the abstract-idea exception to patent eligibility. No. 21-1281, 2023 WL 3440746, at *1 (U.S. May 15, 2023); No. 22-22, 2023 WL 3440747 (U.S. May 15, 2023). No opinion was issued, but the Court noted that Justice Kavanaugh would have heard the cases.
In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis
LATEST NEWS Abstract Spatiotemporally coordinated transformations in epithelial curvature are necessary to generate crypt-villus structures during intestinal development. However, the temporal regulation of mechanotransduction pathways that drive crypt morphogenesis remains understudied. Intestinal organoids have proven useful to study crypt morphogenesis in vitro, yet the reliance on static culture scaffolds limits the ability to assess the temporal effects of changing curvature.
Isolating climatic, tectonic, and lithologic controls on mountain landscape evolution
LATEST NEWS Abstract Establishing that climate exerts an important general influence on topography in tectonically active settings has proven an elusive goal. Here, we show that climates ranging from arid to humid consistently influence fluvial erosional efficiency and thus topography, and this effect is captured by a simple metric that combines channel steepness and mean annual rainfall, ksnQ.
Population-specific vulnerability to ocean change in a multistressor environment
LATEST NEWS Abstract Variation in environmental conditions across a species’ range can alter their responses to environmental change through local adaptation and acclimation. Evolutionary responses, however, may be challenged in ecosystems with tightly coupled environmental conditions, where changes in the covariance of environmental factors may make it more difficult for species to adapt to global change.
Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway
Information Published In Science Advances Volume 9 | Issue 3 January 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
Information Published In Science Advances Volume 9 | Issue 3 January 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
The HIPK2/CDC14B-MeCP2 axis enhances the spindle assembly checkpoint block by promoting cyclin B translation
LATEST NEWS Abstract Mitotic perturbations activate the spindle assembly checkpoint (SAC) that keeps cells in prometaphase with high CDK1 activity. Prolonged mitotic arrest is eventually bypassed by gradual cyclin B decline followed by slippage of cells into G1 without chromosome segregation, a process that promotes cell transformation and drug resistance. Hitherto, the cyclin B1 decay is exclusively defined by mechanisms that involve its proteasomal degradation.
Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections
LATEST NEWS Abstract Bacterial biofilm infections, particularly those of Pseudomonas aeruginosa (PA), have high rates of antimicrobial tolerance and are commonly found in chronic wound and cystic fibrosis lung infections. Combination therapeutics that act synergistically can overcome antimicrobial tolerance; however, the delivery of multiple therapeutics at relevant dosages remains a challenge.
ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning
Abstract Regulation of the Arp2/3 complex is required for productive nucleation of branched actin networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit isoforms, ArpC5 and ArpC5L, have been reported to fine-tune nucleation activity and branch junction stability. We have combined reverse genetics and cellular structural biology to describe how ArpC5 and ArpC5L differentially affect cell migration.
Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics
LATEST NEWS Abstract Cyclic adenosine 3′,5′-monophosphate (cAMP) is a key second messenger in cardiomyocytes responsible for transducing autonomic signals into downstream electrophysiological responses. Previous studies have shown intracellular heterogeneity and compartmentalization of cAMP signaling. However, whether cAMP signaling occurs heterogeneously throughout the intact heart and how this drives sex-dependent functional responses are unknown.
The molecular mechanism of sialic acid transport mediated by Sialin
LATEST NEWS Abstract Malfunction of the sialic acid transporter caused by various genetic mutations in the SLC17A5 gene encoding Sialin leads to a spectrum of neurodegenerative conditions called free sialic acid storage disorders. Unfortunately, how Sialin transports sialic acid/proton (H+) and how pathogenic mutations impair its function are poorly defined.
Covalent-like bondings and abnormal formation of ferroelectric structures in binary ionic salts
Abstract In the Mooser-Pearson diagram, binary ionic compoundss form into nonpolar symmetrical structures with high coordination numbers, while wurtzite structures should appear in the covalent region. Their tetrahedral bonding configurations break the inversion symmetry, with polarizations almost unswitchable due to the high barriers of abrupt breaking and reformation of covalent bonds.
HPV is a cargo for the COPI sorting complex during virus entry
Abstract During entry, human papillomavirus (HPV) traffics from the cell surface to the endosome and then to the trans-Golgi network (TGN) and Golgi apparatus. HPV must transit across the TGN/Golgi and exit these compartments to reach the nucleus to cause infection, although how these steps are accomplished is unclear.
Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling
LATEST NEWS Abstract Breast cancer–associated gene 1 (Brca1) deficiency induces the onset of breast cancer formation, accompanied with extensive genetic alterations. Here, we used both the sleeping beauty transposon mutagenesis system and CRISPR-Cas9–mediated genome-wide screening in mice to identify potential genetic alterations that act synergistically with Brca1 deficiency to promote tumorignesis.
Contextual drive of neuronal responses in mouse V1 in the absence of feedforward input
Abstract Neurons in the primary visual cortex (V1) respond to stimuli in their receptive field (RF), which is defined by the feedforward input from the retina. However, V1 neurons are also sensitive to contextual information outside their RF, even if the RF itself is unstimulated. Here, we examined the cortical circuits for V1 contextual responses to gray disks superimposed on different backgrounds. Contextual responses began late and were strongest in the feedback-recipient layers of V1.
Adsorptive exchange of coccolith biominerals facilitates viral infection
Abstract Marine coccolithophores are globally distributed, unicellular phytoplankton that produce nanopatterned, calcite biominerals (coccoliths). These biominerals are synthesized internally, deposited into an extracellular coccosphere, and routinely released into the external medium, where they profoundly affect the global carbon cycle. The cellular costs and benefits of calcification remain unresolved.
Actin limits egg aneuploidies associated with female reproductive aging
LATEST NEWS Abstract Aging-related centromeric cohesion loss underlies premature separation of sister chromatids and egg aneuploidy in reproductively older females. Here, we show that F-actin maintains chromatid association after cohesion deterioration in aged eggs. F-actin disruption in aged mouse eggs exacerbated untimely dissociation of sister chromatids, while its removal in young eggs induced extensive chromatid separation events generally only seen in advanced reproductive ages.
A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy
LATEST NEWS Abstract Although literature suggests that resistance to TNF inhibitor (TNFi) therapy in patients with ulcerative colitis (UC) is partially linked to immune cell populations in the inflamed region, there is still substantial uncertainty underlying the relevant spatial context.
ESPRESSO: Robust discovery and quantification of transcript isoforms from error-prone long-read RNA-seq data
LATEST NEWS Abstract Long-read RNA sequencing (RNA-seq) holds great potential for characterizing transcriptome variation and full-length transcript isoforms, but the relatively high error rate of current long-read sequencing platforms poses a major challenge. We present ESPRESSO, a computational tool for robust discovery and quantification of transcript isoforms from error-prone long reads.
Altered host protease determinants for SARS-CoV-2 Omicron
Information Published In Science Advances Volume 9 | Issue 3 January 2023 Copyright Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma
Abstract Incomplete surgery of solid tumors is a risk factor for primary treatment failure. Here, we have investigated whether chimeric antigen receptor T cells (CARTs) could be used as an adjuvant therapy to clear residual cancer cells.
How to make causal inferences using texts
Experiment 1 As a starting point, we conduct an analysis of the experimental results reported in (44). The survey experiment was administered in the context of a larger study of public perceptions of the criminal justice system. The survey was conducted in 2000 by telephone random-digit dial and includes 1300 respondents. More details about the survey are available in Cohen et al. (51). In the experiment, respondents were given two scenarios of a criminal offense.
Navigating Global Fintech Patent Eligibility Challenges
Because rights granted by a patent generally extend only as far as the borders of the country granting it, a fintech patent granted in one country will not extend to foreign countries. What's more, fintech finds itself in the crosshairs of patent eligibility questions because many countries have taken specific steps to prevent the granting of patents on pure methods of doing business or finance.
Considerations For Innovators When Navigating Patent Eligibility On The International Stage
To print this article, all you need is to be registered or login on Mondaq.com. Finnegan attorneys Paul Browning, Christopher Johns, Sara Leiman and Yelena Morozova explain some of the differences between patent-eligibility standards in the U.S. and those in other parts of the world. Ever year patentees file more patent applications in a wider range of countries.
CosmoKey Gets A Duo-Over – Federal Circuit Panel Reverses Finding Of Ineligibility - Intellectual Property - United States
United States: CosmoKey Gets A Duo-Over – Federal Circuit Panel Reverses Finding Of Ineligibility 18 November 2021 by Christopher Johns , Sydney Kestle and Elizabeth Ferrill Finnegan, Henderson, Farabow, Garrett & Dunner, LLP Your LinkedIn Connections with the authors To print this article, all you need is to be registered or login on Mondaq.com. In CosmoKey Solutions GMBH & Co. KG v. Duo Security LLC, No. 2020-2043 (Fed. Cir. Oct.
CosmoKey Gets a Duo-Over – Federal Circuit Panel Reverses Finding of Ineligibility
Legal Disclaimer You are responsible for reading, understanding and agreeing to the National Law Review's (NLR’s) and the National Law Forum LLC's Terms of Use and Privacy Policy before using the National Law Review website. The National Law Review is a free to use, no-log in database of legal and business articles. The content and links on www.NatLawReview.com are intended for general information purposes only.
A Fractured Vision Of Eligibility — Split Federal Circuit Panel Finds Digital Camera Claims Ineligible - Intellectual Property - United States
United States: A Fractured Vision Of Eligibility — Split Federal Circuit Panel Finds Digital Camera Claims Ineligible 24 June 2021 by Christopher Johns , Caitlin E. O'Connell and Elizabeth Ferrill Finnegan, Henderson, Farabow, Garrett & Dunner, LLP Your LinkedIn Connections with the authors To print this article, all you need is to be registered or login on Mondaq.com. In Yu v. Apple Inc., No. 2020-1760 (Fed. Cir.
A Fractured Vision of Eligibility — Split Federal Circuit Panel Finds Digital Camera Claims Ineligible
Legal Disclaimer You are responsible for reading, understanding and agreeing to the National Law Review's (NLR’s) and the National Law Forum LLC's Terms of Use and Privacy Policy before using the National Law Review website. The National Law Review is a free to use, no-log in database of legal and business articles. The content and links on www.NatLawReview.com are intended for general information purposes only.
Supremely Confusing On That Complex Word
To print this article, all you need is to be registered or login on Mondaq.com. A patent drafter's selection of even the smallest of words, like "a," may have a significant impact on how a claim is construed. Does "a" mean "at least one"? Or does it mean just "one"? As the case law we explore in this article indicates, it can be both! And as will be seen, recently a split Supreme Court muddled through over 40 pages to try to decide what "a" meant in a particular statute.
Medical students keeping COVID at bay, even in a congregate-living setting
Sign up here to get our daily updates on coronavirus in Minnesota delivered straight to your inbox each afternoon. And go here to see all of MinnPost’s COVID-19 coverage. Christopher Johns At 6 p.m. on a recent Monday our house gathered in the dining room. Seventeen first- and second-year medical students lined up by a dinner spread made by one of our members, as is usual on a normal weeknight. The conversations were energetic, students excited to catch up after a day absorbed in medical minutia.
3 Dead, 2 Children Hospitalized Following High-Speed Collision
by Christopher Johns | Dec 27, 2020 | Car Accident | Texas authorities report that three people are dead and two children are in the hospital following a car collision that ended in both cars catching fire. The crash, which occurred around 12 p.m. on December 20 near the intersection of FM 665 and Country Road 61 near Petronila, is believed to have been caused by speeding.
October 2020 USPTO Fee Increases: The Clock Is Ticking - Intellectual Property - United States
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Into the Hells
Hunting for allies. A rescue mission that goes against the natural order. Time to delve deep. Zeke and his friends have a final few obstacles standing in their way before they can try and find a way into the Hells. Everything to this point has been an effort to rescue their buddy, Balmur. One obstacle happens to be a mythical beast that might sooner eat than help them, but no big deal...right?
The economics of fishing the high seas
Spatial fishing patterns and profitability While fishing is geographically extensive on the high seas, it is perhaps less so than previously assumed. Using a spatial grid with 0.5° resolution, we estimate that fishing occurred in 132 million km2 or 57% of the high seas in 2016; this number reduces to 48% with a grid of 0.25° resolution. Fishing effort in the high seas occurs mostly between latitudes 45°N and 35°S (Fig. 2).
Berkheimer Memorandum: A Big Shift, in Fact | JD Supra
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The MPEP Now Incorporates – and Expands Upon – § 101 Guidance | JD Supra
Since the Supreme Court decided Alice v. CLS Bank in June 2014, the USPTO regularly issues new memoranda explaining its implementation of the § 101 framework. This includes some of the more notable memos for prosecutors: the memo on Enfish v. Microsoft from May 2016, the memo on McRO and BASCOM from November 2016, and dozens of eligibility examples.
The Invention Stack: Harvesting and Protecting Intellectual Property
In his book The Innovation Stack, Jim McKelvey describes going “‘nose-to-toe’ against the world's most dangerous company” and surviving. McKelvey, who co-founded Square with Jack Dorsey in 2009, recalls Amazon copying Square's product and undercutting its pricing. But after about six years, Amazon discontinued its competing product – and even mailed a Square card reader to its former customers. Naturally, this raised questions. Why did Amazon discontinue its competing product?
Cardiopulmonary MR characteristics can estimate mPAP in COPD
Cardiopulmonary MR characteristics can estimate mPAP in COPD Christopher Johns, Dave Capener, Charlotte Hammerton, Kieran Shotton, Charlie Elliot, Robin Condliffe, David Kiely, Jim Wils, Andrew Swift European Respiratory Journal Sep 2016, 48 (suppl 60) PA1884; DOI: 10.1183/13993003.congress-2016.PA1884
Right ventricular MRI characteristics in patients with borderline pulmonary hypertension
Right ventricular MRI characteristics in patients with borderline pulmonary hypertension Kieran Shotton, Henry Walker, Christopher Johns, Dave Capener, Charlie Elliot, Robin Condliffe, Thanos Charalampopoulos, David Kiely, Jim Wild, Andrew Swift European Respiratory Journal Sep 2016, 48 (suppl 60) PA1874; DOI: 10.1183/13993003.congress-2016.PA1874
Lung perfusion: MRI vs SPECT for screening in suspected chronic thromboembolic pulmonary hypertension
Lung perfusion: MRI vs SPECT for screening in suspected chronic thromboembolic pulmonary hypertension Christopher Johns, Smitha Rajaram, David Capener, Andrew Swift, Jim Wild European Respiratory Journal Sep 2016, 48 (suppl 60) PA2457; DOI: 10.1183/13993003.congress-2016.PA2457
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