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Articles by Christopher Kochansky
PLK4 inhibition-mediated centrosome amplification drives anti-tumor activity across euploid solid tumors
Abstract PLK4 is a master regulator of centriole biogenesis. Knockdown or complete inhibition of PLK4 results in centrosome depletion. Recently, it was demonstrated that normal cells can tolerate centriole depletion by utilizing acentriolar condensates of pericentriolar material to function as microtubule organizing centers during mitosis.
Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization
By Jason Causon, Kevin Bateman, and Rolf Kern, SCIEX and Christopher Kochansky, Merck As drug candidates progress through early to late stage drug discovery, more comprehensive metabolic studies are performed to characterize the site of metabolism, to inform researchers working to improve drug performance. MS/MS data is often required to fully characterize the metabolites, but this is difficult when the resulting metabolites become labile.
Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization
By Jason Causon, Kevin Bateman, and Rolf Kern, SCIEX and Christopher Kochansky, Merck As drug candidates progress through early to late stage drug discovery, more comprehensive metabolic studies are performed to characterize the site of metabolism, to inform researchers working to improve drug performance. MS/MS data is often required to fully characterize the metabolites, but this is difficult when the resulting metabolites become labile.
Metabolite Identification Using An Ion Mobility‐Enhanced Data‐Independent Acquisition Strategy and Automated Data Processing
RESEARCH ARTICLE Tatiana Radchenko Corresponding Author E-mail address: tatiana@leadmolecular.com https://orcid.org/0000-0003-4962-7229 Lead Molecular Design, S.L., Sant Cugat Del Valles, Spain Universitat Pompeu Fabra, Pl. de la Merce, 10‐12, Barcelona, Spain Correspondence Tatiana Radchenko, Lead Molecular Design, S. L, Sant Cugat Del Valles, Spain.
Correction: Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry
Fig 6. Proposed metabolites of buserelin and oxytocin found in 120 min incubations with chymotrypsin. In Fig 6 the images for buserelin metabolites M2 and M3 are incorrectly switched. Please see the corrected Fig 6 here. Citation: Radchenko T, Brink A, Siegrist Y, Kochansky C, Bateman A, Fontaine F, et al. (2018) Correction: Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry.
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