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Christopher M Weise

As seen in: Nature
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Articles by Christopher M Weise

Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis

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By Samir Abu-Rumeileh, Henning Großkopf, Alexander Mensch, Antonia Ratti, Julian Conrad, Caroline Stapf, Patrick Oeckl, Gisela Stoltenburg-Didinger, Alessio Maranzano, Petra Steinacker, Christopher M Weise, Lorenzo Barba, Lucio D’Anna, Hans-Wolfgang Klafki, Jens Wiltfang, Vincenzo Silani, Lutz Froelich, Nicola Ticozzi, Lucrezia Hausner, Dietmar Rudolf Thal, Ingolf Lachmann, Federico Verde, Markus Otto, Arthur Guthknecht, Dirk Osterloh, Julia Krippner, Jochen Hans Weishaupt
| Nature Verified
Abstract Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed.
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Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial

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By Paolo Piaggi, Sascha Heinitz, Martin Reinhardt, Christopher M Weise
| ajcn.nutrition.org
Background: Obesity is associated with reduced activation in the left dorsolateral prefrontal cortex (DLPFC), a region of the brain that plays a key role in the support of self-regulatory aspects of eating behavior and inhibitory control. Transcranial direct current stimulation (tDCS) is a noninvasive technique used to modulate brain activity.
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