Fat can be found in almost any part of your body—and despite what social media may make you believe, it's a totally normal part of human anatomy and is nothing to be ashamed of. But some folks, for a plethora of reasons, may be looking to lose fat in certain areas, such as the abdomen, where excess fat tends to accumulate when estrogen levels begin to decline in one's 40s, says Steven R. Smith, M.D., the senior vice president and chief scientific officer at Advent Health Research Institute.