CaCGP combined local delivery of Ca2+ and CGP37157-loaded micelles CGP MPEG-PCL@CGP37157 Micelles EP electroporation GSEA gene set enrichment analysis IRE irreversible electroporation PDAC pancreatic ductal adenocarcinoma TME tumor microenvironment 1 Introduction Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies of the digestive system, characterized by an extremely poor prognosis and continually rising incidence and mortality rates [1].