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Abstract Cleft lip and palate (CLP) are common congenital craniofacial anomalies, but the post-transcriptional mechanisms regulating palatal shelf growth remain incompletely understood. In this study, small RNA sequencing was used to profile miRNA expression during murine palatal shelf development, and miR-124-3p was selected for functional assessment. In situ hybridization detected miR-124-3p in palatal tissues at multiple embryonic stages.
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