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Chuanzhi Duan

As seen in: Nature, Royal Society of Chemistry
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Articles by Chuanzhi Duan

Low-Dose Glucocorticoids Adjunctive to Flow Diverter Therapy for Unruptured Intracranial Aneurysms Improve Cerebrovascular Outcomes

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By Zhuohua Wen, Xiheng Chen, Xin Tong, Chi Huang, Mengshi Huang, Jiancheng Lin, Anqi Xu, Hanyan Yang, Xiru Zhang, Yuanqi Lin, Runze Ge, Hao Yuan, Chao Peng, Yanchao Liu, Fa Jin, Shixing Su, Xin Zhang, Xifeng Li, Zongduo Guo, Ming Lv, Aihua Liu, Chuanzhi Duan, Xin Feng, Jiwan Huang
| Nature Verified
Abstract Flow diverter (FD) implantation is standard for unruptured intracranial aneurysms (UIAs), but cerebrovascular complications persist. This nested study within a prospective multicenter cohort evaluates whether short-term, low-dose glucocorticoid use is associated with cerebrovascular outcomes after FD implantation. Propensity-score matching with exact matching on UIA location yielded 1327 patients (360 glucocorticoid-treated; 967 controls).
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Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage - Cell Death & Disease

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By Chuanzhi Duan
| Nature Verified
Abstract Subarachnoid hemorrhage (SAH) significantly compromises the blood-brain barrier (BBB) and impairs patient recovery. This study elucidates the critical role of astrocytic Neogenin-1 (NEO1) in BBB integrity post-SAH and examines the regulatory effects of hepcidin on endothelial cell (EC) function amid NEO1-mediated disruptions in iron homeostasis.
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