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Chuping Chen

As seen in: Journal of Medical Case Reports, Diabetes Research and Clinical Practice
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Articles by Chuping Chen

Capecitabine-induced severe diabetes and hypokalemia: a case report - Journal of Medical Case Reports

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By Qiaoling Yang, Chuping Chen, Jianmin Ran
| Journal of Medical Case Reports Verified
Case report Open Access Published: 25 April 2022 Journal of Medical Case Reports volume 16, Article number: 163 (2022) Cite this article Abstract Background Capecitabine is widely used in chemotherapy for breast, colorectal, and gastric cancers. The frequent adverse reactions of capecitabine mainly include gastrointestinal side effects, anemia, and cardiovascular toxicity. Here, we report a rare case of severe hyperglycemia and hypokalemia during long-term treatment with capecitabine.
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AGEs-induced MMP-9 activation mediated by Notch1 signaling is involved in impaired wound healing in diabetic rats

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By Ping ZHU, Chuping Chen, Daoai Wu, Guangshu Chen
| Diabetes Research and Clinical Practice Verified
Highlights • 1.Overexpression of MMP-9 is associated with Notch1 signaling in diabetic skin. • 2.RAGE/Notch1/NF-κB/MMP-9 pathway is activated in AGEs-stressed keratinocytes. • 3.Inhibition of MMP-9 activation by Notch signaling promotes diabetic wound closure. Abstract Aims To elucidate the relationship between advanced glycation end products (AGEs), Notch1 signaling, nuclear factor-kappa B (NF-κB), and matrix metalloproteinase-9 (MMP-9) in diabetic wound healing in vitro and in vivo.
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