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Articles by Cindy Ly
A novel fluorescent ocular tracer enables detection of TDP-43 pathology in ALS and related TDP-43 proteinopathies using retinal imaging
Abstract Molecular biomarkers of neurodegenerative disease are positioned to facilitate earlier diagnosis and treatment, therapeutic development, and define disease heterogeneities that inform precision interventions. The retina, an optically accessible extension of the central nervous system, manifests biomarkers for many neurodegenerative diseases, providing an opportunity for simple, non-invasive detection.
Antisense Oligonucleotide Tofersen Distribution in the Central Nervous System of SOD1 -ALS Autopsy Tissue Donors
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Antisense Oligonucleotide Tofersen Distribution in the Central Nervous System of SOD1-ALS Autopsy Tissue Donors Key Points Question What is the biodistribution of tofersen and its impact on SOD1 levels in human central nervous system tissues?
By Amanda J. Guise, Shanu Roemer, Michael Monine, Nicole Harris, Dan Bartlett, Eric M. David, Shanqin Xu, Andrew King, Robert Bowser, Vladislav A. Korobeynikov, John Ravits, Pamela Shaw, Toby Ferguson, Stephanie Fradette, Danielle Graham, Eric Sorenson, Björn Oskarsson, R. Ross Reichard, Dennis W. Dickson, Sabrina Paganoni, Suma Babu, Derek Oakley, Matthew P. Frosch, Timothy Miller, Robert C. Bucelli, Richard Perrin, Cindy Ly, Edward D Plowey, Monica Thanawala Sellon, Luke Jandreski, Sohail Malek, Steve Garafalo, Ivan Nestorov, Margaret D. Ireland, J. Robin Highley
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Strengthening Self-Reliance to Support “Can
Canada's health systems remain vulnerable to supply disruptions due to overreliance on globally sourced health products and limited visibility into domestic manufacturing capacity. This study presents an empirically tested, artificial intelligence—enabled search platform designed to automate the sourcing of health products from Canadian companies.
A Collaborative Approach to Solving Canada’s Heal
Featured Current Issue Past Issues Special Issues Masthead For Authors Healthcare Quarterly 28(1) May 2025 : 46-55.doi:10.12927/hcq.2025.27631 Canada's healthcare supply chain faces persistent disruptions, and its fragility has been well documented.
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function - Nature Communications
Abstract Nuclear loss and cytoplasmic buildup of the RNA-binding protein TDP-43 is a hallmark of ALS and related disorders. While studies using artificial TDP-43 depletion in neurons have revealed changes in gene expression and splicing, their relevance to actual patients remained unclear.
Important Announcement from the Shameless Collective
Announcements November 10th, 2023 by Cindy Ly Comments Illustration Credit: Mallory CK Taylor Dear Shameless Readers, As you may know, at the beginning of this year, Shameless paused production of the magazine to consider how to run a sustainable feminist media organization.
“Yellow Fever” and the Hypersexualization of Asian Women in Film
In Stanley Kubrick's 1987 war film Full Metal Jacket, Papillon Soo-Soo plays a Vietnamese sex worker soliciting American GIs. Scantily clad in a leather slit skirt and teetering high heels, she takes a long, slow drag on her cigarette and recites the lines, " Me so horny. Me love you long time.
Multi-Jurisdictional Collaboration as a Strat
This paper describes a framework that engages diverse leaders and decision-makers across Canada's federal, provincial and territorial jurisdictions to build collaboration that overcomes the silos and competition among jurisdictions during healthcare supply disruptions.
Desert Dazed: 5 Take Aways From Day 3
Cindy Ly is a live music aficionado living in Los Angeles. With more than 100+ shows a year under her belt, Cindy is a pro, yet still on occasion forgets to take her earplugs. Maybe she’ll remember next time. If you can, you can try to catch Cindy dancing Cumbias or running into the mosh pit, you never know.
Desert Daze 2019 Memorable Highlights Day 1 " Highlark
Desert Daze 2019 Memorable Moments Desert Daze kicked off its 2019 edition under warm sunny skies of Moreno Beach in Lake Perris. These are some of the highlights we saw on Friday. // Jessica Pratt As chill and low key as we imagined it. Pratt’s stage set up is bare bones; on one side piano accompaniment by Quiet Signs collaborator Matthew McDermott, and Pratt on the other sitting in a chair playing the guitar while signing her songs.
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