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The polymerases that copy DNA are very good at their job, pairing adenines with thymines and cytosines with guanines at breakneck speed. Their occasional errors are mostly corrected by proofreading functions built into the polymerase itself and by post-replication mismatch repair (MMR). These keep the frequency of mutation low enough to maintain the health of individuals but high enough to allow for the evolution of populations.
Abstract Acute kidney injury (AKI) is a common perioperative complication that is associated with increased mortality. This study investigates the renal gene expression in male Long–Evans rats after prolonged anesthesia and surgery to detect molecular mechanisms that could predispose the kidneys to injury upon further insults.
It’s hoped that an increase in federal funding will help get the wheels of innovation to begin turning again in Canada. Arlen Redekop / Vancouver Sun There’s a disconnect between Canada’s capacity to innovate and our capacity to commercialize those innovations — or so the story goes.
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