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Articles by Claire Guéguen
Beyond viral vectors: an end-to-end platform for rapid CAR-T and CAR-NK generation
This webinar presents a non-viral workflow spanning plasmid engineering, mRNA optimization, production, purification, and immune cell engineering, which offers an alternative to lentiviral vectors for generating CAR-T and CAR-NK cells, using transient mRNA-based engineering to shorten iteration cycles and speed the evaluation of new CAR constructs.
Improved gene delivery and T Cell editing using cell free DNA and novel non viral delivery solutions
Live30 webinars pack the latest innovations and applications into a data-rich 30-minute session. Switching to enzymatically produced DNA formats and optimized non-viral delivery vehicles can address two of the most persistent bottlenecks in gene therapy development: DNA toxicity and suboptimal delivery efficiency.
02.04.25 -- How Atsena Got Its Gene Therapy To Spread Subretinally To Treat XLRS
The company’s novel capsid is delivering therapeutic genes to the fovea without the need for detaching part of the retina. Dramatic Reduction Of Solvent Usage In Pharmaceutical Spray Drying Using volatile processing aids to increase drug solubility in more environmentally friendly solvents, like methanol, reduces the amount of solvent required to manufacture amorphous solid dispersions (ASDs).
Combining AI-powered mRNA design with non-viral delivery to achieve organ-specific targeting
Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format. Attend this webinar to explore how cationic lipid-based transfection coupled with AI-powered mRNA design can enhance expression and tissue specificity for in vivo RNA delivery. Effective tissue-specific delivery remains a key challenge in the development of mRNA therapeutics.
05.14.24 -- The Podcast Post-Episode Recap: Vor Bio's Dr. Robert Ang
Accelerate cell therapy manufacturing and preserve precious sample material with rapid sterility testing Read a new application study showing the benefits of rapid sterility testing when managing the fast-paced process and limited shelf life of a cell therapy workflow. Ensure the quality and safety of your final product while minimizing the risk of product loss and delays. Learn how to improve workflow efficiency and maintain the integrity and effectiveness of your cell therapy product now.
Enabling RNA therapeutics: innovative cationic lipids to improve LNP formulation
07:30 PDT / 10:30 EDT / 15:30 BST / 16:30 CEST DNA and RNA therapeutics are drug products composed of an active genetic component linked to an efficient delivery system, generally lipid nanoparticles (LNPs). Those treatments include both prophylactic vaccines that prevent infection by triggering the patient’s immune system and therapeutic vaccines that will be used to treat and cure patients. Each therapy will require its own LNP formulation depending on the genetic material and targeted tissue.
Efficiency Of jetOPTIMUS® In Hard-To-Transfect Stem Cells: Mesenchymal And Pluripotent Cells To the Test
By Thibaut Benchimol, Alengo Nyamay’antu, and Claire Gueguen The biggest challenge when transfecting stem cells is cell death which has been reported after both non-viral and viral transfection delivery methods(2). Furthermore, as a result of both susceptibility to cell death and fast self-renewal, transfection efficiency can be lower with stem cells than with other cell types.
IL‐10 mRNA levels in whole blood cells correlate with house dust mite allergen immunotherapy efficacy
The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
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