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Clare Wallace

As seen in: Color Research & Application, BioRxiv, Neurology
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Articles by Clare Wallace

Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease

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By Bruno A. Benitez, Clare Wallace, Maulikkumar Patel, Niko-Petteri Nykanen
| BioRxiv
Abstract There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Alzheimers disease (AD). Pathway analysis of post mortem brain-derived proteomic data from AD patients shows that the lysosomal system is perturbed relative to similarly aged unaffected controls. However, it is unclear if these changes contributed to the pathogenesis or are a response to the disease.
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Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease

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By Carla Yuede, Clare Wallace, Todd Davis Verified, Woodrow D. Gardiner
| Color Research & Application Verified
ORIGINAL ARTICLE Carla M. Yuede Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA Search for more papers by this author Clare E.
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Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model

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By John R. Cirrito, Clare Wallace, Ping Yan, Todd Davis Verified
| Neurology Verified
Abstract Background Several neurotransmitter receptors activate signaling pathways that alter processing of the amyloid precursor protein (APP) into β-amyloid (Aβ). Serotonin signaling through a subset of serotonin receptors suppresses Aβ generation. We proposed that escitalopram, the most specific selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter SERT, would suppress Aβ levels in mice.
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Europe, Donmar Warehouse

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By Anja Müller Verified, Clare Wallace
| sierz.co.uk
In the middle of the current decade, there was a mild vogue for reviving a handful of the great plays of the 1990s, such as Mark Ravenhill’s Shopping and Fucking and Patrick Marber’s Closer. Now the Donmar Warehouse’s new artistic director, the energetic Michael Longhurst, has chosen David Greig’s Europe, first staged at the Traverse in Edinburgh in 1994, as his inaugural production. Because it’s a kind of state-of-the-continent tone poem, this feels like a really excellent choice.
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