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We thank Dr. Falsaperla and colleagues for their comments. We agree with many of the points that they make and agree with them that more research on this topic is urgently needed. We want to emphasize that the words “Scylla and Charybdis” are followed by a question mark. They are not meant as a statement.
In early development, expression patterns of cation chloride cotransporters can lead to high concentrations of chloride inside the cell. Depolarizing GABAA receptor responses are important for normal brain development and occur in a sex-, age-, and region-specific pattern.
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