We describe a case of leprosy in an immunocompromised Dutch male whose parents were born in a leprosy-endemic country. The use of immunosuppressive drugs in Mycobacterium leprae infected individuals therefore increases the risk of development of leprosy. Exposure and infection at a young age through his parents is another possible risk factor. Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting.