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Articles by Colm O'Rourke
Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma
To characterise the genome-wide DNA methylation landscapes in AMPAC, we profiled 16 patients with remaining DNA. First, we performed unsupervised hierarchical clustering and principal component analysis on the most variable probes and regions (promoters, genes and enhancers), (figure 5A, online supplemental tables S20 and S21).
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy
chemotherapy liver cholangiocarcinoma Data availability statement Data are available on reasonable request. Transcriptome data have been deposited in Gene Expression Omnibus (GEO) under this manuscript.
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy
Bulk biopsy transcriptomes capture global signalling but lose biological resolution of specific histopathological regions within the tissues. To address this limitation, we performed geospatial macrodissection followed by whole-transcriptome profiling (Tempo-seq) of tumour cores (TCs; 11 LS, 9 RP), tumour stroma (TSs; 5 LS, 6 RP), invasive fronts (IFs; 3 LS, 3 RP) and non-malignant regions (NRs; 4 LS, 4 RP) from the same RPLS biopsies (figure 2E, online supplemental figure S3).
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy
Bulk biopsy transcriptomes capture global signalling but lose biological resolution of specific histopathological regions within the tissues. To address this limitation, we performed geospatial macrodissection followed by whole-transcriptome profiling (Tempo-seq) of tumour cores (TCs; 11 LS, 9 RP), tumour stroma (TSs; 5 LS, 6 RP), invasive fronts (IFs; 3 LS, 3 RP) and non-malignant regions (NRs; 4 LS, 4 RP) from the same RPLS biopsies (figure 2E, online supplemental figure S3).
Numbers games are still source of division
The big carrot for having the new minor age at 17 is that it ensures nobody from this age group can play adult football. This means adult competitions can proceed without worrying about the talented player wanted by every manager. These were usually very good players who were often on county minor teams, which held up club matches when the two clashed.
Photoblog: Honeytone Cody [The Basement, York] January 13, 2012
As a farewell gig before heading off on their The Welcome Noise tour around Germany, Honeytone Cody put on a fantastic night of music with support acts Fawn Spots, …And The Hangnails and the acoustic stylings of Robert Green. The night started with Green, a student from York College, who armed with only his guitar and his voice had what appeared to be his own personal fan club sat against the barrier.
EMA track for anti-bullying cause
A single and video released today by EMA sets out to promote the cause of children who are being bullied. Proceeds from the sale of ‘Take One Two’ shall be donated to The Jamie Isaacs Foundation, a New York-based organisation dedicated to providing youth advocacy and lobbying for the passing of anti-bullying legislation. The video, using clips originally filmed in a trailer park in South Dakota in the mid 1990s, features EMA with some of her friends at the time.
E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment
Metabolism and Chemical Biology Francisco González-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O'Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela-Rey, Marta Palomo-Irigoyen, Beatriz Gómez-Santos, Diego Sáenz de Urturi, Maitane Núñez-García, Juan L. García-Rodríguez, Larraitz Fernández-Ares, Xabier Buqué, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C.
E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment
Research Article Francisco Gonzalez-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O'Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela Rey, Marta Palomo-Irigoyen, Beatriz Gómez-Santos, Diego Sáenz de Urturi, Maitane Núñez-García, Juan L. García-Rodríguez, Larraitz Fernández-Ares, Xabier Buqué, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C. Delgado, Naroa Goikoetxea-Usandizaga, Richard Lee, Sanjay Bhanot, Igotz Delgado, Maria J.
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