CONFLICT OF INTEREST STATEMENT Passage Bio has filed a patent application based on the findings presented in this work. Supporting Information REFERENCES , , , , , , & (2021). Towards the development of digital twins for the bio-manufacturing industry. Advances in Biochemical Engineering/Biotechnology, 176, 1–34. , , , & (2011). Carbon metabolism limits recombinant protein production in Pichia pastoris. Biotechnology and Bioengineering, 108(8), 1942–1953. Hemgenix—A gene therapy for hemophilia B.
