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1 Introduction Glioblastoma remains a major threat to human longevity, and its clinical management is largely confined to the standard tri-modality regimens of surgical resection, radiotherapy, and temozolomide chemotherapy [1-3]. However, the fundamental limitation lies in the inherent inability of macroscopic tumor resection to address diffusely infiltrating tumor cells, a shortcoming that inexorably precipitates local recurrence [4, 5].
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