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Abstract Objective: To compare the short-term biochemical efficacy and safety of microwave ablation (MWA) and parathyroidectomy (PTX) in patients with primary hyperparathyroidism (PHPT), and to identify independent predictors of treatment failure. Materials and methods: This retrospective cohort study included 173 consecutive patients with PHPT treated with MWA (n = 46) or PTX (n = 127) between January 2019 and January 2025.
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