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Connull Leslie

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Articles by Connull Leslie

Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models - Scientific Reports

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By m. MORALES, Sally M. Lansley, Wee Loong Chin, Caitlin M. Tilsed, Nicola Principe, Connull Leslie, Francois Rwandamuriye, Emma de Jong, Joel Kidman, Rachael M. Zemek, Catherine Rinaldi, Timo Lassmann, Anthony Bosco, Y. C. Gary Lee, Richard Lake Verified, Jonathan Chee, W. Joost Lesterhuis, Breana J. Vitali
| Nature Verified
Abstract Mesothelioma is a cancer derived from mesothelial cells, most commonly arising from the pleura or the peritoneum. Immune checkpoint therapy (ICT) has shown survival benefit for pleural mesothelioma, but little is known about the response in peritoneal mesothelioma. Most preclinical mesothelioma models involve subcutaneous cancer cell implantation, which lacks the relevant tumour microenvironment of peritoneal mesothelioma and does not resemble the clinical presentation.
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Prolonged Survival in Anaplastic Thyroid Cancer: Insights From Multi‐Modal Treatment

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By Bella Nguyen, Richard Gauci, Katie Meehan, Connull Leslie
| Wiley Online Library Verified
Aims Anaplastic thyroid cancer (ATC) is a rare and aggressive malignancy with limited treatment options and a poor prognosis. This study evaluates the outcomes of patients with locally advanced or metastatic ATC treated at two tertiary centres, focusing on the efficacy of pembrolizumab and lenvatinib, and the impact of BRAF status. Method A retrospective review of 16 ATC patients treated between January 2018 and June 2024 at two tertiary Australian hospitals was conducted.
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