Skip To Main Content
Constance A. Mitchell on Muck Rack

Constance A. Mitchell

Washington, D.C.
As seen in: Wiley Online Library
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile
Back to Constance A. Mitchell’s profile

Articles by Constance A. Mitchell

Within‐laboratory reproducibility of Ames test results: Are repeat tests necessary?

|
By Constance A. Mitchell, Stefan Pfuhler, Yang Liao, Errol Zeiger
| Wiley Online Library Verified
1 INTRODUCTION The Ames test was developed in the early 1970s as a relatively simple and sensitive method for identifying mutagenic chemicals (Ames et al., 1975) by measuring gene mutation induction in Salmonella typhimurium and Escherichia coli bacterial strains. Although the test measures mutations in bacterial genes, a positive (mutagenic) response has ≥70% sensitivity for rodent carcinogenicity depending on the chemical classes tested (Zeiger, 1998).
Open in Who Shared Issue with article?

Complex Interplay Among Nuclear Receptor Ligands, Cytosine Methylation, and the Metabolome in Driving Tris(1,3-dichloro-2-propyl)phosphate-Induced Epiboly Defects in Zebrafish

|
By Subham Dasgupta, Vanessa Cheng, Constance A. Mitchell, Jay S. Kirkwood
| American Chemical Society
Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) is a high-production-volume organophosphate flame retardant (OPFR) that induces epiboly defects during zebrafish embryogenesis, leading to the disruption of dorsoventral patterning. Therefore, the objectives of this study were to (1) identify the potential mechanisms involved in TDCIPP-induced epiboly defects and (2) determine whether coexposure to triphenyl phosphate (TPHP)—an OPFR commonly detected with TDCIPP—enhances or mitigates epiboly defects.
Open in Who Shared Issue with article?

Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the Early-Blastula Stage Alters the Normal Trajectory of Zebrafish Embryogenesis

|
By David Volz, Subham Dasgupta, Vanessa Cheng, Constance A. Mitchell
| ACS Publications
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is an organophosphate flame retardant used around the world. Within zebrafish, we previously showed that initiation of TDCIPP exposure during cleavage (0.75 h post-fertilization, hpf) results in epiboly disruption at 6 hpf, leading to dorsalized embryos by 24 hpf, a phenotype that mimics the effects of dorsomorphin (DMP), a bone morphogenetic protein (BMP) antagonist that dorsalizes embryos in the absence of epiboly defects.
Open in Who Shared Issue with article?
Show More