Research ArticleTranslational Human Pathophysiology Richard A Jacobson, Kiedo Wienholts, Ashley J Williamson, Sara Gaines, Sanjiv Hyoju, Harry van Goor, Alexander Zaborin, Benjamin D Shogan, Olga Zaborina, and John C. Alverdy Abstract Perforations, anastomotic leak and subsequent intraabdominal sepsis are among the most common and feared complications of invasive interventions in the colon and remaining intestinal tract.