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In order to increase understanding of how T3 induces hypertrophy and/or terminal maturation and how these processes mark OA pathophysiology, we performed cartilage RNA-seq analysis of control and T3 treated human osteochondral explants that were harvested from total knee replacement surgery material. The dataset consisted of 16 paired cartilage samples from 8 donors, 6 males and 2 females and with an average age of 69.9 years (range 59-76).
Sterenborg, R. B. T. M. et al. (2024) Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. Nature Communications, 15, 888. (doi: 10.1038/s41467-024-44701-9) (PMID:38291025) (PMCID:PMC10828500) Text 317742.pdf - Published Version Available under License Creative Commons Attribution. 10MB Abstract To date only a fraction of the genetic footprint of thyroid function has been clarified.
Abstract Background Failing of intrinsic chondrocyte repair after mechanical stress is known as one of the most important initiators of osteoarthritis. Nonetheless, insight into these early mechano-pathophysiological processes in age-related human articular cartilage is still lacking. Such insights are needed to advance clinical development.
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