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RNA Biology Kimberly A. Parker, Alex J. Gooding, Saba Valadkhan and William P. Schiemann DOI: 10.1158/1541-7786.MCR-21-0137 Published December 2021 Abstract Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with its aggressive phenotype being attributed to chemotherapy resistance, metastatic dissemination, and rapid disease recurrence.
Introduction Breast cancer (BC) has a high incidence and mortality among women in addition to critical socioeconomic impacts (Bray et al. 2018). Over the past 50 y, BC has become a major health problem for women worldwide with, in 2018, more than 2 million new cases diagnosed (12% of all new cancer cases and 25% of all cancers in women) and more than 600,000 deaths (Bray et al. 2018).
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