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doi: 10.1016/j.jpeds.2023.113468. Online ahead of print. Affiliations Affiliations 1 Duke University, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina; Department of Psychology, University of Utah, Salt Lake City, Utah. Electronic address: sarah.maylott@duke.edu. 2 Duke University, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina; Department of Psychology, University of Utah, Salt Lake City, Utah.
This study provides the strongest evidence to date supporting the hypothesis that advanced parental ages at the time of birth are independently associated with risk for ASD in the offspring; with no support for any modification by the sex of the child. There was also evidence for a combined parental age effect. The risk was highest when both parents were older, but the risk was also increased among disparately aged parents.
Importance: Maternal infections and fever during pregnancy are associated with increased risk for autism spectrum disorders (ASDs). To our knowledge, no study has investigated the association between influenza vaccination during pregnancy and ASD. Objective: To investigate the association between influenza infection and vaccination during pregnancy and ASD risk.
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