Abstract Systemic vascular dysfunction has been implicated in parkinsonism, but prospective evidence on the cumulative burden of multisystem vascular-related disease (MVRD) and its relation to genetic susceptibility remains limited. We included 456,862 UK Biobank participants of White ethnicity with available genetic data who were free of diagnosed parkinsonism at baseline. MVRD comprised ischemic heart disease, stroke, chronic kidney disease, retinopathy, and neuropathy.
