We study topological states of matter in quasicrystals, which do not rely on crystalline order. In the absence of a band-structure description and spin-orbit coupling, we show that a three-dimensional quasicrystal can nevertheless form a topological insulator. It relies on a combination of noncrystallographic rotational symmetry of quasicrystals and electronic orbital space symmetry, which is the quasicrystalline counterpart of the topological crystalline insulator.