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BiH je na rubu otvaranja pristupnih pregovora s EU-om, ali pred njom stoje brojni izazovi povezani s političkom voljom, pravnim usklađivanjem i provedbom reformi, dok EU i dalje prati situaciju i postavlja jasne uvjete za nastavak europskog puta zemlje. Današnji posjet visoke predstavnice Europske unije za vanjske poslove i sigurnosnu politiku te potpredsjednice Europske komisije Kaje Kallas dolazi u zanimljivom političkom trenutku u BiH.
Background: The phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is often dysregulated in HR+ BC and is associated with resistance to endocrine therapy (ET). Alpelisib (BYL719; PI3K?-specific inhibitor) and fulvestrant showed signs of antitumor activity in patients (pts) with estrogen receptor-positive (ER+), HER2– advanced BC (phase I), especially in PIK3CA-altered tumors (Janku et al. SABCS 2014, PD5-5).
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