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Background: Plasmablastic lymphoma (PBL) is a high-grade neoplasm with features of both lymphoma and myeloma. It was originally described primarily in people with HIV in the pre-antiretroviral era and nearly always fatal. However, a recent study of the AIDS Malignancy Consortium with EPOCH showed a 70% two-year event free survival (Ramos, Blood 2020). Currently, the majority of PBL patients do not have HIV (Ciaccio, ASH 2020).
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