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Abstract Introduction Formulation research benefits from high-throughput excipient screening methods, considering the ever-growing excipient space. We investigate the use of 384-well plates as freeze-drying containers and for subsequent analyses, to screen the effect of excipients on the stability of proteins during freeze-drying. Methods For both the preparation and analysis methods of a range of β-galactosidase formulations, an 8-tip pipetting robot was used.
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1, 1, 2, 2, 2, 1 and 1,* 1 Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9700 RB Groningen, The Netherlands 2 The Netherlands Organization for Applied Scientific Research (TNO), 5656 AE, Eindhoven, The Netherlands * Author to whom correspondence should be addressed.
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