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Abstract CD177 is a membrane protein present on some, but not all, circulating neutrophils in a given individual, dividing the total neutrophil population into two distinct subsets. We investigated proteomic differences between CD177pos and CD177neg neutrophils from healthy human subjects. Neutrophils were isolated from peripheral blood, followed by magnetic separation based on the surface expression of CD177.
Introduction There are several rare monogenic autoinflammatory bone disorders, e.g., deficiency of interleukin-1 receptor antagonist (DIRA, affected gene IL1RN), Majeed syndrome (affected gene LPIN2), cherubism (affected gene SH3BP2), as well as the recently described disease LIRSA/CRMO3 (affected gene IL1R1) (1–5).
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