1Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China 2School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom Purpose: Yerba Maté, a traditional South American herbal infusion abundant in bioactive compounds, has been suggested to offer health benefits including lipid regulation and weight management. However, existing evidence remains inconclusive.