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Abstract Few studies have explored stratification biomarkers of synucleinopathies, including Parkinson’s disease (PD), and idiopathic rapid-eye-movement sleep behavior disorder (iRBD), a prodromal stage for these conditions. Oral/salivary microbiomes are altered in PD, highlighting their potential role in both pathogenesis and diagnosis. We analyzed 249 salivary microbiomes of controls and patients with iRBD and synucleinopathies in cross-sectional studies.
Abstract Salivary microbiome alterations associated with cognitive function have been reported in patients with neurodegenerative diseases. Gut microorganisms can modulate therapeutic efficacy via drug metabolism. Additionally, several drugs against diabetes and inflammatory bowel disease can lead to microbial dysbiosis. However, the effect of central nervous system (CNS) drug use on the microbiome remains unknown.
Open AccessArticle by Yuki Ishida 1, Yo Mabuchi 1,2, Yuna Naraoka 1, Daisuke Hisamatsu 1 and Chihiro Akazawa 1,* 1 Intractable Disease Research Center, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan 2 Department of Clinical Regenerative Medicine, Fujita Health University, Toyoake 470-1192, Japan * Author to whom correspondence should be addressed. Int. J. Mol. Sci.
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Daisuke Hisamatsu , Natsumi Itakura , Yo Mabuchi , Rion Ozaki , Eriko Grace Suto , Yuna Naraoka , Akari Ikeda , Lisa Ito and Chihiro Akazawa * Intractable Disease Research Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan * Author to whom correspondence should be addressed.
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