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Dakui Luo

As seen in: Nature, Wiley Online Library, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles by Dakui Luo

GALE is a tumor-intrinsic checkpoint of Vγ9Vδ2 T cell-mediated killing Original

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By Zezhi Shan, Dongdong Wang, Zening Zheng, Zilan Ye, Shiyu Mao, Yaxu Li, Yadong Guo, Qi Wu, Yanjin Wang, Qiao Ran, Yanrong Yang, Tingting Niu, Dakui Luo, Junyong Weng, Lei Yu, Liming Wei, Xin Ge, Xinxiang Li, Ping Wang, Longyan Xie, Linjun Weng
| Nature Verified
Abstract Vγ9Vδ2 T cells mediate HLA-independent targeting of tumor cells, offering unique opportunities for cancer immunotherapy, yet their therapeutic efficacy remains limited. Here, using a genome-wide CRISPR screen, we identify UDP-galactose 4-epimerase (GALE) as a tumor-intrinsic checkpoint that restricts Vγ9Vδ2 T cell-mediated killing.
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Prognosis and clinicopathological features of patients with early‐onset and late‐onset colorectal cancer with second primary malignancies

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By Fan Chen, Jiayu Chen, Dakui Luo, Ruijia Zhang
| Wiley Online Library Verified
Introduction Colorectal cancer (CRC) ranks as the third most common malignancy worldwide and the second most common cause of cancer-related deaths.1 The full implementation and popularization of CRC screening strategies in recent years have led to a significant decrease in morbidity and mortality rates in the USA and European countries.2, 3 However, the incidence of early-onset CRC (eoCRC; diagnosed < 50 years of age) has been on the rise globally.4-6 The reasons for this upward trend are not...
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