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Results Individuals exposed to CS frequently show impaired neurobehaviors and metabolic disturbances, but the biological mechanism is unclear.31 To explore the underlying changes occurring in response to CS, we established a CS model based on the Friedman protocol,32 which involved 14 days of electric foot shock (FS) (Figure 1A). Here, the treated mice were referred to as FS mice.
Abstract Alzheimer’s disease (AD) is an irreversible neurodegenerative disease characterized by cognitive decline. The precise molecular mechanisms that underlie the pathogenesis of AD remain elusive. Here we show that glycoprotein nonmetastatic melanoma protein B (GPNMB) is produced by microglia and transferred to astrocytes through extracellular vesicles (EVs) in PS19 tau pathology mice.
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