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Dan Dongeun

As seen in: Nature, Oxford University Press (OUP)
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Articles by Dan Dongeun

Fetoplacental Disposition and Toxicity of Cadmium in Mice Lacking the Bcrp Transporter

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By Dan Dongeun
| Oxford University Press (OUP)
The environmental toxicant cadmium (Cd) impairs the growth of rodents and humans in utero which in turn heightens susceptibility to diseases later in life. We previously demonstrated that the maternal-facing efflux transporter, breast cancer resistance protein (human BCRP/ABCG2, mouse Bcrp/Abcg2) confers resistance against Cd toxicity in human trophoblasts. In the current study, we sought to determine whether the absence of Bcrp alters the fetoplacental disposition and toxicity of Cd in mice.
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Fetoplacental disposition and toxicity of cadmium in mice lacking the Bcrp transporter

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By Dan Dongeun
| Oxford University Press (OUP)
The environmental toxicant cadmium (Cd) impairs the growth of rodents and humans in utero which in turn heightens susceptibility to diseases later in life. We previously demonstrated that the maternal-facing efflux transporter, breast cancer resistance protein (human BCRP/ABCG2, mouse Bcrp/Abcg2) confers resistance against Cd toxicity in human trophoblasts. In the current study, we sought to determine whether the absence of Bcrp alters the fetoplacental disposition and toxicity of Cd in mice.
Open in Who Shared Issue with article?

A microphysiological model of human trophoblast invasion during implantation - Nature Communications

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By Ju Young, NSF Nano-scale Science, Dan Dongeun
| Nature Verified
Abstract Successful establishment of pregnancy requires adhesion of an embryo to the endometrium and subsequent invasion into the maternal tissue. Abnormalities in this critical process of implantation and placentation lead to many pregnancy complications. Here we present a microenigneered system to model a complex sequence of orchestrated multicellular events that plays an essential role in early pregnancy.
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