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Graphical Abstract Targeted LNPs Delivery to the Bone Marrow In article number 2301377, Dana Tarab-Ravski, Dan Peer, and co-workers develop targeted lipid nanoparticles to efficiently deliver therapeutic RNA to multiple myeloma cells in the bone marrow. In a novel xenograft multiple myeloma (MM) mouse model, this delivery system demonstrates its ability to specifically target MM cells and produce a positive clinical outcome in mice engrafted with MM.
Abstract Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable. RNA therapy delivered via lipid nanoparticles (LNPs) has the potential to be a promising cancer treatment, however, its clinical implementation is limited due to inefficient delivery to non-hepatic tissues.
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