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Pleural metabolic profile change associated with MPE in lung adenocarcinoma patients To determine the alteration of pleural metabolites from MPE in lung adenocarcinoma patients, we conducted untargeted metabolomics through LC-MS/MS. Molecules were analyzed using both positive and negative ionization. Pearson's correlation analysis between quality controls showed higher noise in the positive ion mode (Figure ). Therefore, a negative ion model was finally used.
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