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[Skip to Navigation] Figure. Forest Plot of Odds Ratios (ORs) of Number of Different Antiepileptic Drugs (AEDs) and Number of AEDs Issues for Parkinson Disease (PD) JAMA Neurol. 2023;80(2):183-187. doi:10.1001/jamaneurol.2022.4699 Key Points Question Are antiepileptic drugs (AEDs) associated with increased risk of developing Parkinson disease (PD)?
Abstract Objective We sought to determine whether genetic risk modifies the effect of environmental risk factors for multiple sclerosis (MS). To test this hypothesis, we tested for statistical interaction between polygenic risk scores (PRS) capturing genetic susceptibility to MS and environmental risk factors for MS in UK Biobank. Methods People with MS were identified within UK Biobank using ICD-10–coded MS or self-report.
New Results View ORCID ProfileBenjamin Meir Jacobs, Alastair Noyce, Jonathan P Bestwick, Daniel Belete, Gavin Giovannoni, Ruth Dobson doi: https://doi.org/10.1101/2020.03.01.971739 Abstract Importance: Multiple Sclerosis (MS) is a common neuro-inflammatory disorder caused by a combination of environmental exposures and genetic risk factors. Interaction between environmental and genetic factors may impact on MS risk.
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