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Daniel Bonsor

As seen in: Nature, PLOS
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Articles by Daniel Bonsor

Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors - Nature Communications

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By Daniel Bonsor, Jacob Potter, Vanessa Wall, Dwight V. Nissley, Frank McCormick
| Nature Verified
Abstract RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2–RAS–PP1C complex. MRAS forms a high-affinity SHOC2–MRAS–PP1C (SMP) complex, while canonical RAS isoforms (KRAS, HRAS, NRAS) form analogous but lower-affinity assemblies. Yet, cancers driven by oncogenic KRAS, HRAS, or NRAS remain strongly SHOC2-dependent, suggesting that these weaker complexes contribute to tumorigenesis.
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An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments

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By Marko Nedeljkovic, Sandra Postel, Yingying Xing, Daniel Bonsor, PLOS Pathogens
| PLOS
The ridged flagellar filaments characteristic of P. aeruginosa PAO1 are found in diverse bacteria The structure of the flagellar filament of P. aeruginosa PAO1 is markedly different from that of S. Typhimurium. In Salmonella, outer domains D2 and D3 are clearly separated from each other and from neighboring outer domains and do not interact [19]. Conversely, the recently published structure of the C.
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